The operate of SIK1 in tumorigenesis. SIK1 can be a tumor suppressor gene, which plays a significant regulatory function in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 also can advertise m… Read More